Beilstein J. Org. Chem.2020,16, 2911–2919, doi:10.3762/bjoc.16.240
, Universitätsstrasse 7, 45141 Essen, Germany 10.3762/bjoc.16.240 Abstract Ultraviolet resonanceRaman (UVRR) spectroscopy is a powerful vibrational spectroscopic technique for the label-free monitoring of molecular recognition of peptides or proteins with supramolecular ligands such as guanidiniocarbonyl pyrroles
the results from density functional theory (DFT) calculations.
Keywords: GCI; GCP; guanidiniocarbonyl indole; guanidiniocarbonyl pyrrole; UVRR; Raman spectroscopy; resonanceRaman; Introduction
Supramolecular ligands are capable to selectively bind to peptides and proteins via reversible non
millimolar concentrations due to the small Raman scattering cross sections. Therefore, the biologically relevant submillimolar concentrations of GCP are not detectable by conventional (off-resonant) Raman spectroscopy. This limitation can be overcome by resonanceRaman (RR) spectroscopy because it offers a
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Graphical Abstract
Figure 1:
UV–vis absorption spectra of GCP ethyl amide [9] (in grey) and GCI ethyl amide (in green) at 200 µM co...